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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GSDMA All Species: 19.7
Human Site: T259 Identified Species: 61.9
UniProt: Q96QA5 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96QA5 NP_835465.2 445 49379 T259 D V H E G F R T L K E E V Q R
Chimpanzee Pan troglodytes XP_001171203 445 49374 T259 D V H E G F R T L K E E V Q R
Rhesus Macaque Macaca mulatta XP_001094878 449 49807 T263 D V H E G F G T L K E E V Q R
Dog Lupus familis XP_850338 442 49582 T256 E E H E N F K T L K E E V Q R
Cat Felis silvestris
Mouse Mus musculus Q9EST1 446 49575 T260 E M H E D F K T L K E E V Q R
Rat Rattus norvegicus P85967 474 53233 Y284 P V H L D F K Y L E K E V F L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505287 446 48775 A260 E V P E D F G A L Q E E V E S
Chicken Gallus gallus NP_001026532 452 49940 A253 F A H T E V E A L E E E V K E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 94.8 84.9 N.A. 88.3 31.2 N.A. 66.3 32.2 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 100 96.4 91 N.A. 94.1 48.5 N.A. 80 52.6 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 73.3 N.A. 73.3 40 N.A. 46.6 33.3 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 93.3 86.6 N.A. 93.3 60 N.A. 66.6 46.6 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 13 0 0 0 0 0 25 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 38 0 0 0 38 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 38 13 0 75 13 0 13 0 0 25 88 100 0 13 13 % E
% Phe: 13 0 0 0 0 88 0 0 0 0 0 0 0 13 0 % F
% Gly: 0 0 0 0 38 0 25 0 0 0 0 0 0 0 0 % G
% His: 0 0 88 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 38 0 0 63 13 0 0 13 0 % K
% Leu: 0 0 0 13 0 0 0 0 100 0 0 0 0 0 13 % L
% Met: 0 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 13 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 13 0 13 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 13 0 0 0 63 0 % Q
% Arg: 0 0 0 0 0 0 25 0 0 0 0 0 0 0 63 % R
% Ser: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 % S
% Thr: 0 0 0 13 0 0 0 63 0 0 0 0 0 0 0 % T
% Val: 0 63 0 0 0 13 0 0 0 0 0 0 100 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 13 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _